The FDA approved JANUMET® XR (sitagliptin and metformin hydrochloride (HCl) extended-release) tablets, a treatment for type 2 diabetes that combines sitagliptin, which is the active component of JANUVIA® (sitagliptin), with extended-release metformin…. CASE. A 49-year-old African-American man, a computer engineer, seeks a second opinion because his clinician tells him that his diabetes is uncontrolled, but the patient is sure that it is well controlled. Detailed Glipizide dosage information for adults and the elderly. Includes dosages for Diabetes Type 2; plus renal, liver and dialysis adjustments. Sulfonylureas, the first drug group introduced into the U.S. in 1955, stimulates the beta cells to produce more insulin. These drugs have kept many Type 2’s off injected insulin. Initially, 5 mg PO once daily given 30 minutes before breakfast. Geriatric patients or those patients at risk for hypoglycemia may be started on 2.5 mg/day. Glipizide is the generic form of the prescription drug Glucotrol. It's used along with diet and exercise to help control blood-sugar levels in people who have type 2 diabetes. Hypoglycemia. Of the 580 patients that received Glipizide XL in clinical trials, 3.4% had hypoglycemia documented by a blood-glucose measurement 60 mg/dL and/or symptoms believed to be associated with hypoglycemia and 2.6% of patients discontinued for this reason. CASE. A 51-year-old construction worker seeks your advice because of frequent hypoglycemic reactions. Three years ago, the patient was diagnosed with type 2 diabetes following six months of polyuria, blurred vision, and weight loss. Initial doses of 0.2 to 0.4 mg/kg/day PO divided twice daily have been used in several small studies (n = 4 to 15, ages 2.5 to 15.6 years). Doses were gradually titrated up to the maximally tolerated dose, ranging from 0.4 to 2.4 mg/kg/day. Metformin comes as a liquid, a tablet, and an extended-release (long-acting) tablet to take by mouth. The liquid is usually taken with meals one or two times a day.